Origin Tsunade

Tsunade was born and raised in the Hidden Leaf Village as the grand daughter of the village founder, the First Hokage making her also the grandniece of the  

Tsunade In Her Youth          

Second Hokage. She grew up to become a powerful ninja and an expert in Medical Justu, as a member of the Three Sannin; but terrible luck in gambling. She did so by being the student of the Third Hokage, allong with Orochimaru and Jiraiya, the other two Sannin ------> furthermore